Apple will base its London operation at the regenerated Battersea Power Station.
The Grade II-listed building, which has remained derelict for 33 years since it ceased powering and lighting London, is undergoing a multibillion-pound restoration.
The tech giant will be the largest office tenant at the Malaysian-backed development on the banks of the River Thames when it takes the top six floors in the central boiler house, room for 1,400 staff.
Apple employees based in eight offices around the capital, forming 鈥渃entral鈥� functions in areas such as finance and human resources, will all move there.
Apple said in a statement that 鈥渙ur new London campus [will be] a magnificent new development at one of the city鈥檚 best-known landmarks鈥�.
It added: 鈥淭his is a great opportunity to have our entire team working and collaborating in one location while supporting the renovation of a neighbourhood rich with history.鈥�
British supercar maker McLaren聽recently denied that it is in talks with Apple over a strategic investment or full-blown takeover.
The famous former coal-fired power station designed by Sir Giles Gilbert Scott is planned to include three floors of shops, 253 apartments around a 鈥済arden square in the sky鈥�, a 2,000-seater auditorium and cinemas in a scheme designed by London architects Wilkinson Eyre.
There have been three previous attempts to regenerate the area, while Chelsea FC was rejected when it applied to build a new stadium on the site.
Battersea Power Station Development Company鈥檚 chief executive Rob Tincknell said: 鈥淲e are delighted Apple chose to make this their home in 2021.
鈥淚t is a testament to not only the fantastic building but the wider regeneration of the 42-acre site, which offers a carefully curated mix of homes, businesses and leisure amid extraordinary open spaces and new transport links.
鈥淚t has always been our clear objective to create one of London鈥檚 most thriving new communities and this commitment from Apple will undoubtedly help us achieve this goal.鈥�
Apple recently courted controversy after ditching the traditional headphone jack on the iPhone 7.
London Mayor Sadiq Khan said: 鈥淚鈥檓 delighted Apple is moving into Battersea Power Station, helping to generate new jobs and economic prosperity for London.
鈥淚t is a further sign London is open to the world鈥檚 biggest brands and the leading city for trade and investment.鈥�
Chancellor Philip Hammond said: 鈥淎pple鈥檚 decision further strengthens London鈥檚 position as a global technology hub and demonstrates how the UK is at the forefront of the next steps in the tech revolution.
鈥淚t鈥檚 another vote of confidence in the UK economy.鈥�
Wandsworth council鈥檚 leader Ravi Govindia said: 鈥淚鈥檓 very pleased to give Apple a warm welcome.
鈥淭hey will become the largest employer in the borough and we are hugely excited that they will play a keen and active role in our community.鈥�